Myeloid-Derived Suppressor Cells.
نویسنده
چکیده
منابع مشابه
Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model
Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...
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Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...
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Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could ...
متن کاملمروری بر نقش سلول های مهاری مشتق از رده میلوئیدی در تنظیم سیستم ایمنی
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and together with regulatory T cells (Tregs) have a remarkable ability to suppress immune responses. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. Limited data are...
متن کاملInduction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composition of the bone marrow, blood, and spleen by inducing myelopoiesis and enhancing the frequency of regulatory T cells in the CD4 population. Expansi...
متن کامل0097. Myeloid-derived suppressor cells attenuate inflammation and improve the survival of microbial sepsis
Introduction Myeloid-derived suppressor cells (MDSCs) are heterogeneous population of immature myeloid cells with suppressive activity, containing precursor of granulocytes, macrophages, and dendritic cells [1-3]. They expand in inflammatory conditions and regulate immune responses. However, the role that MDSCs played in other chronic or acute inflammatory conditions like sepsis is not well und...
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عنوان ژورنال:
- Viral immunology
دوره 30 2 شماره
صفحات -
تاریخ انتشار 2017